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Gene Information
Gene ID:45815
Organism:Drosophila melanogaster (Fly)
Genetic Location:26F5-26F6
Physical Location:6671777-6673343 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Spn27A
P Value:2.20E-05
Note:Slow up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_143767.2NP_652024.1NT_033779.4 range: 6671777..6673343, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004857enzyme inhibitor activityMolecular FunctionIDA (14667416)
GO:0004867serine-type endopeptidase inhibitor activityMolecular FunctionISS
GO:0004867serine-type endopeptidase inhibitor activityMolecular FunctionNAS
GO:0035009negative regulation of melanization defense responseBiological ProcessTAS (14734104)
GO:0035009negative regulation of melanization defense responseBiological ProcessIMP (12408809|12456640)
GO:0035006melanization defense responseBiological ProcessTAS (15032585)
GO:0009950dorsal/ventral axis specificationBiological ProcessIMP (14654000|14667416)
GO:0009611response to woundingBiological ProcessIMP (12408809)
GO:0009608response to symbiontBiological ProcessIMP (12408809)
GO:0008063Toll signaling pathwayBiological ProcessIDA (14667416)
GO:0035011melanotic encapsulation of foreign targetBiological ProcessIMP (12408809)
Other Database Cross Links
NCBI Entrez Gene:45815