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Gene Information
Gene ID:4628
Symbol:MYH10
Full Name:myosin, heavy chain 10, non-muscle
Alias:MGC134913|MGC134914|NMMHCB
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17p13
Physical Location:8318254-8474760 on NC_000017.9, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 77579 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Linkage Dataset
MarkerLODP valueLocation (bp)
D17S1852  10456226
Region:8456226-12456226
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005964.1NP_005955.1NC_000017.9 range: 8318254..8474760, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0032154cleavage furrowCellular ComponentIDA (7699007|11029059)
GO:0001725stress fiberCellular ComponentIDA (7699007)
GO:0030496midbodyCellular ComponentIDA (11029059)
GO:0005737cytoplasmCellular ComponentIDA (7699007)
GO:0005938cell cortexCellular ComponentIDA (7699007)
GO:0016459myosin complexCellular ComponentNAS (7499478)
GO:0000146microfilament motor activityMolecular FunctionIDA (15845534)
GO:0043531ADP bindingMolecular FunctionIDA (15845534)
GO:0030898actin-dependent ATPase activityMolecular FunctionIDA (15845534)
GO:0051015actin filament bindingMolecular FunctionIDA (15845534)
GO:0005524ATP bindingMolecular FunctionNAS (7782316)
GO:0005516calmodulin bindingMolecular FunctionIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0008360regulation of cell shapeBiological ProcessIEA
GO:0030048actin filament-based movementBiological ProcessIDA (15845534)
GO:0000281cytokinesis after mitosisBiological ProcessIDA (15774463)
GO:0008150biological_processBiological ProcessND
Other Database Cross Links
NCBI Entrez Gene:4628
HGNC:7568
Ensembl:ENSG00000133026
MIM:160776
HPRD:01178
HuGE Navigator:4628
dbSNP:MYH10
GeneCard:MYH10
AceView:MYH10