ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MYH10

Full Name:

myosin, heavy chain 10, non-muscle

Alias:

MGC134913|MGC134914|NMMHCB

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p13

Physical Location:

8318254-8474760 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 77579 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S1852

10456226

Region:		8456226-12456226
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005964.1	NP_005955.1	NC_000017.9 range: 8318254..8474760, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0032154	cleavage furrow	Cellular Component	IDA (7699007\|11029059)
GO:0001725	stress fiber	Cellular Component	IDA (7699007)
GO:0030496	midbody	Cellular Component	IDA (11029059)
GO:0005737	cytoplasm	Cellular Component	IDA (7699007)
GO:0005938	cell cortex	Cellular Component	IDA (7699007)
GO:0016459	myosin complex	Cellular Component	NAS (7499478)
GO:0000146	microfilament motor activity	Molecular Function	IDA (15845534)
GO:0043531	ADP binding	Molecular Function	IDA (15845534)
GO:0030898	actin-dependent ATPase activity	Molecular Function	IDA (15845534)
GO:0051015	actin filament binding	Molecular Function	IDA (15845534)
GO:0005524	ATP binding	Molecular Function	NAS (7782316)
GO:0005516	calmodulin binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0008360	regulation of cell shape	Biological Process	IEA
GO:0030048	actin filament-based movement	Biological Process	IDA (15845534)
GO:0000281	cytokinesis after mitosis	Biological Process	IDA (15774463)
GO:0008150	biological_process	Biological Process	ND