ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MYL2

Full Name:

myosin, light chain 2, regulatory, cardiac, slow

Alias:

CMH10|DKFZp779C0562|MLC2

Organism:

Homo sapiens (Human)

Chromosome:

12

Genetic Location:

12q23-q24.3

Physical Location:

109833031-109842763 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.75535
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000432.3	NP_000423.2	NC_000012.10 range: 109833031..109842763, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030017	sarcomere	Cellular Component	TAS (16754800)
GO:0016459	myosin complex	Cellular Component	IEA
GO:0003774	motor activity	Molecular Function	IEA
GO:0032036	myosin heavy chain binding	Molecular Function	NAS (8287067)
GO:0008307	structural constituent of muscle	Molecular Function	TAS (8673105)
GO:0005515	protein binding	Molecular Function	IPI (16555005)
GO:0005509	calcium ion binding	Molecular Function	IDA (11102452)
GO:0003785	actin monomer binding	Molecular Function	IDA (9180271)
GO:0006942	regulation of striated muscle contraction	Biological Process	TAS (8673105)
GO:0030308	negative regulation of cell growth	Biological Process	IMP (15824735)
GO:0055010	ventricular cardiac muscle morphogenesis	Biological Process	IMP (8673105)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000111245

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: