| Gene Information |
| Gene ID: | | 4671 |
| Symbol: | | NAIP |
| Full Name: | | NLR family, apoptosis inhibitory protein |
| Alias: | | BIRC1|FLJ42520|NLRB1|psiNAIP |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 5 |
| Genetic Location: | | 5q13.1 |
| Physical Location: | | 70300065-70356696 on NC_000005.8, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | NAIP | | Original ID2: | | U192521 |
| | Dataset Information | | Name: | | 11093800 | | Method: | | Microarray | | Tissue: | | SH-SY5Y neuroblastoma cells | | Phenotype: | | Ethanol response | | Publication: | | Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed | | Summary: | | We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment. |
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| Linkage Dataset | | Marker | LOD | P value | Location (bp) | |
| D5S647 | | | 66282906 | | Region: | | 66282906-76193808 | | Phenotype: | | Alcoholism phenotype along with age, gender, and P300 or constraint | | Name: | | 15211641 | | Method: | | Linkage | | Publication: | | Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed | | Summary: | | A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb). |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005622 | intracellular | Cellular Component | IEA | |
| GO:0000166 | nucleotide binding | Molecular Function | IEA | |
| GO:0005524 | ATP binding | Molecular Function | IEA | |
| GO:0017111 | nucleoside-triphosphatase activity | Molecular Function | IEA | |
| GO:0006915 | apoptosis | Biological Process | IEA | |
| GO:0006916 | anti-apoptosis | Biological Process | TAS (8552191) | |
| GO:0007399 | nervous system development | Biological Process | TAS (7813013) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 4671 |
| HGNC: | | 7634 |
| Ensembl: | | ENSG00000081770 |
| MIM: | | 600355 |
| HPRD: | | |
| HuGE Navigator: | | 4671 |
| dbSNP: | | NAIP |
| GeneCard: | | NAIP |
| AceView: | | NAIP |
