| Gene Information |
| Gene ID: | | 47082 |
| Symbol: | | Adf1 |
| Alias: | | Adf 1|Adf-1|CG15845|l(2)01349|l(2)04065|nal |
| Organism: | | Drosophila melanogaster (Fly) |
| Chromosome: | | 2R |
| Genetic Location: | | 42C3-42C3 |
| Physical Location: | | 2549773-2555591 on NT_033778.3 |
| Gene Type: | | protein-coding |
| Human Ortholog: | | This gene has no human ortholog. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Adf1 | | P Value: | | 4.78E-02 | | Note: | | Acute down-regulation |
| | Dataset Information | | Name: | | 17054780 | | Method: | | Microarray | | Phenotype: | | Ethanol response | | Publication: | | Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed | | Summary: | | We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005634 | nucleus | Cellular Component | IDA (10939338) | |
| GO:0005634 | nucleus | Cellular Component | ISS (10471706) | |
| GO:0005634 | nucleus | Cellular Component | NAS | |
| GO:0003677 | DNA binding | Molecular Function | IEA | |
| GO:0003702 | RNA polymerase II transcription factor activity | Molecular Function | NAS | |
| GO:0016251 | general RNA polymerase II transcription factor activity | Molecular Function | ISS (10471706) | |
| GO:0008355 | olfactory learning | Biological Process | NAS (11462211) | |
| GO:0040011 | locomotion | Biological Process | IMP (16547170) | |
| GO:0045941 | positive regulation of transcription | Biological Process | TAS (11741030) | |
| GO:0008345 | larval locomotory behavior | Biological Process | NAS (11715043) | |
| GO:0007616 | long-term memory | Biological Process | TAS (11741030) | |
| GO:0007613 | memory | Biological Process | IMP (10939338) | |
| GO:0007611 | learning and/or memory | Biological Process | NAS (11715043) | |
| GO:0007416 | synaptogenesis | Biological Process | IMP (10939338) | |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | Biological Process | NAS | |
| GO:0048813 | dendrite morphogenesis | Biological Process | IMP (16547170) | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 47082 |
| FLYBASE: | | FBgn0000054 |
