ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nmdmc

Alias:

151767_at|CG18466|DNMDMC|unnamed

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

85C3-85C3

Physical Location:

4868225-4876270 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10797 Symbol (Name): MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase)

Ortholog Status:

The human GeneID 10797 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nmdmc
P Value:		6.11E-03
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	NAS
GO:0005739	mitochondrion	Cellular Component	ISS (8485162)
GO:0000287	magnesium ion binding	Molecular Function	NAS
GO:0005488	binding	Molecular Function	IEA
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Molecular Function	NAS
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Molecular Function	ISS
GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	Molecular Function	NAS
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	Molecular Function	NAS
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	Molecular Function	ISS (8485162)
GO:0005975	carbohydrate metabolic process	Biological Process	ISS
GO:0009256	10-formyltetrahydrofolate metabolic process	Biological Process	ISS
GO:0009396	folic acid and derivative biosynthetic process	Biological Process	IEA