ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

NKTR

Full Name:

natural killer-tumor recognition sequence

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3p23-p21

Physical Location:

42617150-42665236 on NC_000003.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18087 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.529509
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005385.3	NP_005376.2	NC_000003.10 range: 42617150..42665236

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	NR
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Molecular Function	IEA
GO:0016018	cyclosporin A binding	Molecular Function	TAS (8421688)
GO:0016853	isomerase activity	Molecular Function	IEA
GO:0006457	protein folding	Biological Process	IEA