ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ttk

Alias:

0037/17|0250/25|0438/31|0702/07|1049/07|1119/04|1184/16|1209/05|1209/10|1260/10|1281/04|1325/15|1372/08|1396/14|1418/06|3540|5125|5311|CG11558|CG1856|E(yan)100D|FTZ-F2|TTK88|Ttk69|anon-EST:Liang-2.9|clone 2.9|ftzf2/ttk|l(3)02667|l(3)j2A1|l(3)j7B8|osn

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

100D1-100D1

Physical Location:

27539605-27561113 on NT_033777.2

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		ttk
P Value:		1.79E-02
Note:		Slow up-regulation

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_080172.2	NP_524911.3	NT_033777.2 range: 27539605..27561113
NM_170564.1	NP_733443.1	NT_033777.2 range: 27539605..27561113
NM_170565.1	NP_733444.1	NT_033777.2 range: 27539605..27561113
NM_170566.1	NP_733445.1	NT_033777.2 range: 27539605..27561113
NM_170567.1	NP_733446.1	NT_033777.2 range: 27539605..27561113
NM_170568.1	NP_733447.1	NT_033777.2 range: 27539605..27561113

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	NAS
GO:0005700	polytene chromosome	Cellular Component	IDA (11743021)
GO:0016564	transcription repressor activity	Molecular Function	NAS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0016566	specific transcriptional repressor activity	Molecular Function	IMP (15306652)
GO:0005515	protein binding	Molecular Function	IPI (15306652)
GO:0003704	specific RNA polymerase II transcription factor activity	Molecular Function	NAS
GO:0003682	chromatin binding	Molecular Function	IDA (15306652)
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0046843	dorsal appendage formation	Biological Process	IMP (12490195)
GO:0045467	R7 cell development	Biological Process	TAS (10929403)
GO:0048666	neuron development	Biological Process	IMP (16547170)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	NAS
GO:0030707	ovarian follicle cell development	Biological Process	IMP (16542414)
GO:0007422	peripheral nervous system development	Biological Process	TAS (8060613)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	NAS
GO:0001709	cell fate determination	Biological Process	TAS (15018932)
GO:0048813	dendrite morphogenesis	Biological Process	IMP (16547170)