ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

l(1)dd4

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

12B4-12B4

Physical Location:

13630599-13638687 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10426 Symbol (Name): TUBGCP3 (tubulin, gamma complex associated protein 3)

Ortholog Status:

The human GeneID 10426 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		l(1)dd4
P Value:		4.69E-02
Note:		Transient down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_080180.2	NP_524919.2	NC_004354.3 range: 13630599..13638687, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005875	microtubule associated complex	Cellular Component	ISS (10908588)
GO:0008275	gamma-tubulin small complex	Cellular Component	NAS
GO:0008275	gamma-tubulin small complex	Cellular Component	IPI (11134079)
GO:0008275	gamma-tubulin small complex	Cellular Component	IDA (10037793)
GO:0008017	microtubule binding	Molecular Function	ISS (10908588)
GO:0051011	microtubule minus-end binding	Molecular Function	IDA (11134079)
GO:0043015	gamma-tubulin binding	Molecular Function	IDA (12631720)
GO:0007126	meiosis	Biological Process	IMP (12571290)
GO:0051297	centrosome organization and biogenesis	Biological Process	IMP (17412918)
GO:0007017	microtubule-based process	Biological Process	ISS (10908588)
GO:0007020	microtubule nucleation	Biological Process	IDA (10037793\|11134079)
GO:0007052	mitotic spindle organization and biogenesis	Biological Process	IMP (17412918)
GO:0007127	meiosis I	Biological Process	IMP (12571290)
GO:0051322	anaphase	Biological Process	IMP (12571290)