ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Full Name:

nucleoside phosphorylase

Alias:

FLJ94043|FLJ97288|FLJ97312|MGC117396|MGC125915|MGC125916|PNP|PRO1837|PUNP

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q13.1

Physical Location:

20007381-20015087 on NC_000014.7

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		NP
Original ID2:		T47964

Dataset Information

Name:		11093800
Method:		Microarray
Tissue:		SH-SY5Y neuroblastoma cells
Phenotype:		Ethanol response
Publication:		Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:		We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.

Gene Information

Original ID1:

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000270.2	NP_000261.2	NC_000014.7 range: 20007381..20015087

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (6771276)
GO:0004731	purine-nucleoside phosphorylase activity	Molecular Function	EXP (6771276)
GO:0004731	purine-nucleoside phosphorylase activity	Molecular Function	IDA (16964310)
GO:0004731	purine-nucleoside phosphorylase activity	Molecular Function	IEA
GO:0042102	positive regulation of T cell proliferation	Biological Process	IDA (16964310)
GO:0006304	DNA modification	Biological Process	TAS (10884411)
GO:0006148	inosine catabolic process	Biological Process	IDA (16964310)
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Biological Process	TAS (3029074)
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Biological Process	IEA
GO:0046638	positive regulation of alpha-beta T cell differentiation	Biological Process	IDA (16964310)