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Gene Information
Gene ID:4860
Full Name:nucleoside phosphorylase
Organism:Homo sapiens (Human)
Genetic Location:14q13.1
Physical Location:20007381-20015087 on NC_000014.7
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:NP
Original ID2:T47964
Dataset Information
Tissue:SH-SY5Y neuroblastoma cells
Phenotype:Ethanol response
Publication:Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.
Gene Information
Original ID1:NP
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000270.2NP_000261.2NC_000014.7 range: 20007381..20015087
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (6771276)
GO:0004731purine-nucleoside phosphorylase activityMolecular FunctionEXP (6771276)
GO:0004731purine-nucleoside phosphorylase activityMolecular FunctionIDA (16964310)
GO:0004731purine-nucleoside phosphorylase activityMolecular FunctionIEA
GO:0042102positive regulation of T cell proliferationBiological ProcessIDA (16964310)
GO:0006304DNA modificationBiological ProcessTAS (10884411)
GO:0006148inosine catabolic processBiological ProcessIDA (16964310)
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic processBiological ProcessTAS (3029074)
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic processBiological ProcessIEA
GO:0046638positive regulation of alpha-beta T cell differentiationBiological ProcessIDA (16964310)
Other Database Cross Links
NCBI Entrez Gene:4860
HuGE Navigator:4860