Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:4887
Symbol:NPY2R
Full Name:neuropeptide Y receptor Y2
Organism:Homo sapiens (Human)
Chromosome:4
Genetic Location:4q31
Physical Location:156349231-156357677 on NC_000004.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:NPY2R
Dataset Information
Name:18477577
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Information
Original ID1:NPY2R
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000910.2NP_000901.1NC_000004.10 range: 156349231..156357677
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (7592910)
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionTAS (1321422)
GO:0004983neuropeptide Y receptor activityMolecular FunctionTAS (7559383)
GO:0005246calcium channel regulator activityMolecular FunctionTAS (8132547)
GO:0007626locomotory behaviorBiological ProcessTAS (9692752)
GO:0007623circadian rhythmBiological ProcessNR
GO:0007193G-protein signaling, adenylate cyclase inhibiting pathwayBiological ProcessTAS (7559383)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
GO:0007165signal transductionBiological ProcessIEA
GO:0007631feeding behaviorBiological ProcessNR
Other Database Cross Links
NCBI Entrez Gene:4887
HGNC:7957
Ensembl:ENSG00000185149
MIM:162642
HPRD:01216
HuGE Navigator:4887
dbSNP:NPY2R
GeneCard:NPY2R
AceView:NPY2R