ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

mod(mdg4)

Alias:

BcDNA:GH07769|BcDNA:SD03001|CG15500|CG15501|CG15802|CG18151|CG32491|CG7836|CG7859|CG8076|Doom|E(var)129|E(var)3-93D|E(var)93D|E-(var)3-93D|E-var(3)1|E-var(3)3|MOD(MDG4)56.3|Mod(mdg)4|Mod[mdg4]|bpd|l(3)03852|l(3)L3101|l(3)j2B7|mnm|mod|mod(gypsy)|mod(m

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

93D7-93D9

Physical Location:

17177330-17203120 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		mod(mdg4)
P Value:		1.73E-02
Note:		Transient down-regulation

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001104386.1	NP_001097856.1	NT_033777.2 range: 17177330..17203120, complement
NM_001104387.1	NP_001097857.1	NT_033777.2 range: 17177330..17203120, complement
NM_001104388.1	NP_001097858.1	NT_033777.2 range: 17177330..17203120, complement
NM_080197.2	NP_524936.2	NT_033777.2 range: 17177330..17203120, complement
NM_163877.1	NP_732619.1	NT_033777.2 range: 17177330..17203120, complement
NM_163878.1	NP_732620.1	NT_033777.2 range: 17177330..17203120, complement
NM_163879.1	NP_732621.1	NT_033777.2 range: 17177330..17203120, complement
NM_163880.1	NP_732622.1	NT_033777.2 range: 17177330..17203120, complement
NM_163881.1	NP_732623.1	NT_033777.2 range: 17177330..17203120, complement
NM_163882.1	NP_732624.1	NT_033777.2 range: 17177330..17203120, complement
NM_163883.1	NP_732625.1	NT_033777.2 range: 17177330..17203120, complement
NM_163884.1	NP_732626.1	NT_033777.2 range: 17177330..17203120, complement
NM_163885.1	NP_732627.1	NT_033777.2 range: 17177330..17203120, complement
NM_163886.1	NP_732628.1	NT_033777.2 range: 17177330..17203120, complement
NM_163887.1	NP_732629.1	NT_033777.2 range: 17177330..17203120, complement
NM_163888.1	NP_732630.1	NT_033777.2 range: 17177330..17203120, complement
NM_163889.1	NP_732631.1	NT_033777.2 range: 17177330..17203120, complement
NM_163890.1	NP_732632.1	NT_033777.2 range: 17177330..17203120, complement
NM_163891.1	NP_732633.1	NT_033777.2 range: 17177330..17203120, complement
NM_163892.1	NP_732634.1	NT_033777.2 range: 17177330..17203120, complement
NM_163893.1	NP_732635.1	NT_033777.2 range: 17177330..17203120, complement
NM_163894.1	NP_732636.1	NT_033777.2 range: 17177330..17203120, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000785	chromatin	Cellular Component	IMP (7664338)
GO:0005886	plasma membrane	Cellular Component	ISS (11024164)
GO:0005730	nucleolus	Cellular Component	IDA (16286005)
GO:0005700	polytene chromosome	Cellular Component	IDA (10790390)
GO:0005634	nucleus	Cellular Component	NAS (12386928)
GO:0005634	nucleus	Cellular Component	IDA (10790390)
GO:0000794	condensed nuclear chromosome	Cellular Component	IDA (16286005)
GO:0005515	protein binding	Molecular Function	IPI (8248257)
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	NAS
GO:0003682	chromatin binding	Molecular Function	IMP (7664338)
GO:0008195	phosphatidate phosphatase activity	Molecular Function	ISS (11024164)
GO:0042981	regulation of apoptosis	Biological Process	IMP (9111355)
GO:0008354	germ cell migration	Biological Process	IMP (11024164)
GO:0008354	germ cell migration	Biological Process	IGI (11024164)
GO:0007141	male meiosis I	Biological Process	IMP (17277376)
GO:0007060	male meiosis chromosome segregation	Biological Process	IMP (17277376)
GO:0006997	nuclear organization and biogenesis	Biological Process	TAS (12386928)
GO:0006917	induction of apoptosis	Biological Process	TAS (12386928)
GO:0006917	induction of apoptosis	Biological Process	IMP (9111355)
GO:0006325	establishment and/or maintenance of chromatin architecture	Biological Process	NAS
GO:0001672	regulation of chromatin assembly or disassembly	Biological Process	IMP (7664338)
GO:0048477	oogenesis	Biological Process	IMP (8978055\|10790390)