ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dut

Full Name:

deoxyuridine triphosphatase

Alias:

Dutp

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q36

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.6102
Original ID2:		Dut
Fold Change:		1.39
P Value:		0.00116
Note:		higher levels in hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEP (8910358)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEP (8910358)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0042975	peroxisome proliferator activated receptor binding	Molecular Function	IDA (8910358)
GO:0030547	receptor inhibitor activity	Molecular Function	IDA (8910358)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004170	dUTP diphosphatase activity	Molecular Function	IEA
GO:0009117	nucleotide metabolic process	Biological Process	IEA
GO:0046080	dUTP metabolic process	Biological Process	IEA