ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Purb

Full Name:

purine rich element binding protein B

Alias:

pur-beta

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

14q21

Physical Location:

87230345-87232804 on NC_005113.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5814 Symbol (Name): PURB (purine-rich element binding protein B)

Ortholog Status:

The human GeneID 5814 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		pur-beta
Fold Change:		1.17
P Value:		0.001
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001017503.1	NP_001017503.1	NC_005113.2 range: 87230345..87232804, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005662	DNA replication factor A complex	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IDA
GO:0046332	SMAD binding	Molecular Function	IEA
GO:0032422	purine-rich negative regulatory element binding	Molecular Function	IDA
GO:0016566	specific transcriptional repressor activity	Molecular Function	IDA
GO:0008134	transcription factor binding	Molecular Function	ISS
GO:0000900	translation repressor activity, nucleic acid binding	Molecular Function	IDA
GO:0005515	protein binding	Molecular Function	ISS
GO:0003690	double-stranded DNA binding	Molecular Function	ISS
GO:0003697	single-stranded DNA binding	Molecular Function	ISS
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	ISS
GO:0003729	mRNA binding	Molecular Function	ISS
GO:0046332	SMAD binding	Molecular Function	ISS
GO:0006350	transcription	Biological Process	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	ISS