ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cyp11b1

Full Name:

cytochrome P450, subfamily 11B, polypeptide 1

Alias:

Cp11ba|RATCP11BA

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

7q34

Physical Location:

112977394-112984079 on NC_005106.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1584 Symbol (Name): CYP11B1 (cytochrome P450, family 11, subfamily B, polypeptide 1)

Ortholog Status:

The human GeneID 1584 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cyp11b1
Fold Change:		-1.21
P Value:		0.005
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_012537.2	NP_036669.2	NC_005106.2 range: 112977394..112984079, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0030176	integral to endoplasmic reticulum membrane	Cellular Component	IDA (11796518)
GO:0016020	membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IDA (8674848)
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	ISS
GO:0004497	monooxygenase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0020037	heme binding	Molecular Function	IEA
GO:0047783	corticosterone 18-monooxygenase activity	Molecular Function	ISS
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0005496	steroid binding	Molecular Function	IDA (16405651)
GO:0004507	steroid 11-beta-monooxygenase activity	Molecular Function	IEA
GO:0004507	steroid 11-beta-monooxygenase activity	Molecular Function	IDA (11796518\|16405651)
GO:0006694	steroid biosynthetic process	Biological Process	IDA (16405651)
GO:0006704	glucocorticoid biosynthetic process	Biological Process	ISS
GO:0008202	steroid metabolic process	Biological Process	TAS (16179417)
GO:0008211	glucocorticoid metabolic process	Biological Process	TAS (11796518)
GO:0006700	C21-steroid hormone biosynthetic process	Biological Process	IEA