| Gene Information |
| Gene ID: | | 5020 |
| Symbol: | | OXT |
| Full Name: | | oxytocin, prepro- (neurophysin I) |
| Alias: | | MGC126890|MGC126892|OT|OT-NPI |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 20 |
| Genetic Location: | | 20p13 |
| Physical Location: | | 3000265-3001161 on NC_000020.9 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
|
| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | 18477577 | | Method: | | Addiction array gene list | | Publication: | | Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed | | Summary: | | To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior. |
| | Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
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|
| Gene Information | | Original ID | No. of Publications | Phenotype | |
| OXT | 1 | Alcoholism |
| | HuGE Navigator Dataset | | Name: | | HuGE Navigator | | Method: | | Literature data mining | | Publication: | | Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008]. | | Summary: | | HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | IEA | |
| GO:0005179 | hormone activity | Molecular Function | IEA | |
| GO:0005185 | neurohypophyseal hormone activity | Molecular Function | IEA | |
| GO:0007165 | signal transduction | Biological Process | TAS (10218979) | |
| GO:0007567 | parturition | Biological Process | NR | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 5020 |
| HGNC: | | 8528 |
| Ensembl: | | ENSG00000101405 |
| MIM: | | 167050 |
| HPRD: | | 08880 |
| HuGE Navigator: | | 5020 |
| dbSNP: | | OXT |
| GeneCard: | | OXT |
| AceView: | | OXT |
