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Gene Information
Gene ID:50484
Symbol:RRM2B
Full Name:ribonucleotide reductase M2 B (TP53 inducible)
Alias:DKFZp686M05248|MGC102856|MGC42116|p53R2
Organism:Homo sapiens (Human)
Chromosome:8
Genetic Location:8q23.1
Physical Location:103285906-103320521 on NC_000008.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.512592
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_015713.3NP_056528.2NC_000008.9 range: 103285906..103320521, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0004748ribonucleoside-diphosphate reductase activityMolecular FunctionIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0006260DNA replicationBiological ProcessIEA
GO:0006281DNA repairBiological ProcessIEA
GO:0009186deoxyribonucleoside diphosphate metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:50484
HGNC:17296
Ensembl:ENSG00000048392
MIM:604712
HPRD:05276
HuGE Navigator:50484
dbSNP:RRM2B
GeneCard:RRM2B
AceView:RRM2B