ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Slc23a2

Full Name:

solute carrier family 23 (nucleobase transporters), member 2

Alias:

SVCT2

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q36

Physical Location:

119796375-119886010 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9962 Symbol (Name): SLC23A2 (solute carrier family 23 (nucleobase transporters), member 2)

Ortholog Status:

The human GeneID 9962 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Slc23a2
Fold Change:		1.19
P Value:		0.003
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Slc23a2
Fold Change:		-1.16
P Value:		0.005
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Gene Information

Original ID1:		Slc23a2
Fold Change:		1.22
P Value:		0.001
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017316.1	NP_059012.1	NC_005102.2 range: 119796375..119886010, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	IDA (10331392)
GO:0016020	membrane	Cellular Component	IEA
GO:0005215	transporter activity	Molecular Function	IDA (10331392)
GO:0015293	symporter activity	Molecular Function	IEA
GO:0008520	L-ascorbate:sodium symporter activity	Molecular Function	TAS (10331392)
GO:0008520	L-ascorbate:sodium symporter activity	Molecular Function	ISS
GO:0008520	L-ascorbate:sodium symporter activity	Molecular Function	IMP (10331392)
GO:0005215	transporter activity	Molecular Function	IEA
GO:0031402	sodium ion binding	Molecular Function	IEA
GO:0006979	response to oxidative stress	Biological Process	IEP (12887688)
GO:0006814	sodium ion transport	Biological Process	IEA
GO:0015882	L-ascorbic acid transport	Biological Process	IMP (10331392)
GO:0006811	ion transport	Biological Process	IEA
GO:0019852	L-ascorbic acid metabolic process	Biological Process	IMP (10331392)