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Gene Information
Gene ID:50645
Full Name:RAB27A, member RAS oncogene family
Organism:Rattus norvegicus (Rat)
Genetic Location:8q24
Physical Location:77798829-77861089 on NC_005107.2
Gene Type:protein-coding
Human Ortholog:GeneID: 5873    Symbol (Name): RAB27A (RAB27A, member RAS oncogene family)
Ortholog Status:The human GeneID 5873 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rab27a
Fold Change:-1.23
P Value:0.007
Note:Differential expression between ethanol and water groups in amygdala
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_017317.2NP_059013.1NC_005107.2 range: 77798829..77861089
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0042470melanosomeCellular ComponentISS
GO:0016324apical plasma membraneCellular ComponentIDA (17067543)
GO:0030141secretory granuleCellular ComponentIDA (15465017)
GO:0030141secretory granuleCellular ComponentISS
GO:0030425dendriteCellular ComponentISS
GO:0030667secretory granule membraneCellular ComponentIDA (17067543)
GO:0005794Golgi apparatusCellular ComponentISS
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0030141secretory granuleCellular ComponentIEA
GO:0042470melanosomeCellular ComponentIEA
GO:0001750photoreceptor outer segmentCellular ComponentISS
GO:0001750photoreceptor outer segmentCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0031489myosin V bindingMolecular FunctionIEA
GO:0031489myosin V bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0005525GTP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIDA (17067543)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0015031protein transportBiological ProcessIEA
GO:0032402melanosome transportBiological ProcessISS
GO:0043316cytotoxic T cell degranulationBiological ProcessIEA
GO:0043316cytotoxic T cell degranulationBiological ProcessISS
GO:0043320natural killer cell degranulationBiological ProcessIEA
GO:0043320natural killer cell degranulationBiological ProcessISS
GO:0043473pigmentationBiological ProcessIEA
GO:0043473pigmentationBiological ProcessISS
GO:0051875pigment granule localizationBiological ProcessISS
GO:0032402melanosome transportBiological ProcessIEA
GO:0032400melanosome localizationBiological ProcessISS
GO:0032400melanosome localizationBiological ProcessIEA
GO:0016192vesicle-mediated transportBiological ProcessIEA
GO:0016192vesicle-mediated transportBiological ProcessISS
GO:0007596blood coagulationBiological ProcessISS
GO:0007596blood coagulationBiological ProcessIEA
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
GO:0006887exocytosisBiological ProcessTAS (17067543)
GO:0030318melanocyte differentiationBiological ProcessIEA
GO:0030318melanocyte differentiationBiological ProcessISS
GO:0006605protein targetingBiological ProcessISS
GO:0006605protein targetingBiological ProcessIEA
GO:0051904pigment granule transportBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:50645