ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PAM

Full Name:

peptidylglycine alpha-amidating monooxygenase

Alias:

PAL|PHM

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q14-q21

Physical Location:

102229425-102393315 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 18484 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

PAM

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D5S644

95838450

Region:		95838450-103990852
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000790	nuclear chromatin	Cellular Component	IDA (10601332)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	IEA
GO:0030141	secretory granule	Cellular Component	ISS (7590286)
GO:0030141	secretory granule	Cellular Component	NAS (7999037)
GO:0000793	condensed chromosome	Cellular Component	IDA (10601332)
GO:0031418	L-ascorbic acid binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (9837933)
GO:0003682	chromatin binding	Molecular Function	IDA (10601332)
GO:0004497	monooxygenase activity	Molecular Function	IEA
GO:0004504	peptidylglycine monooxygenase activity	Molecular Function	IEA
GO:0004504	peptidylglycine monooxygenase activity	Molecular Function	NAS (7590286\|7999037)
GO:0004598	peptidylamidoglycolate lyase activity	Molecular Function	IEA
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0009987	cellular process	Biological Process	IEA
GO:0007076	mitotic chromosome condensation	Biological Process	IMP (10601332)
GO:0006518	peptide metabolic process	Biological Process	NAS (7999037)
GO:0001519	peptide amidation	Biological Process	ISS (7590286)
GO:0006464	protein modification process	Biological Process	TAS (2357221)