ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pam

Full Name:

peptidylglycine alpha-amidating monooxygenase

Alias:

PHM

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 D|1 57.5 cM

Physical Location:

99717670-99873835 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5066 Symbol (Name): PAM (peptidylglycine alpha-amidating monooxygenase)

Ortholog Status:

The human GeneID 5066 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pam
Original ID2:		U79523

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Ap1q	Alcohol Preference Drinking	1	76	45-95 (cM)	4.5		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_013626.3	NP_038654.2	NC_000067.5 range: 99717670..99873835, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	TAS (10219055)
GO:0005829	cytosol	Cellular Component	TAS (10219055)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0031418	L-ascorbic acid binding	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (8910496)
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0004598	peptidylamidoglycolate lyase activity	Molecular Function	IEA
GO:0004504	peptidylglycine monooxygenase activity	Molecular Function	TAS (10219055)
GO:0004497	monooxygenase activity	Molecular Function	IEA
GO:0006518	peptide metabolic process	Biological Process	TAS (10219055)