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Gene Information
Gene ID:50671
Full Name:fatty acid synthase
Organism:Rattus norvegicus (Rat)
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Fasn
Fold Change:1.13
P Value:0.008
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0042470melanosomeCellular ComponentIEA
GO:0005575cellular_componentCellular ComponentND
GO:0004313[acyl-carrier-protein] S-acetyltransferase activityMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0016788hydrolase activity, acting on ester bondsMolecular FunctionIEA
GO:0016829lyase activityMolecular FunctionIEA
GO:0031177phosphopantetheine bindingMolecular FunctionIEA
GO:0042802identical protein bindingMolecular FunctionIPI
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0048037cofactor bindingMolecular FunctionIEA
GO:0004320oleoyl-[acyl-carrier-protein] hydrolase activityMolecular FunctionIEA
GO:0004319enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activityMolecular FunctionIEA
GO:00043173-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activityMolecular FunctionIEA
GO:00043163-oxoacyl-[acyl-carrier-protein] reductase activityMolecular FunctionIEA
GO:00043153-oxoacyl-[acyl-carrier-protein] synthase activityMolecular FunctionIEA
GO:0004314[acyl-carrier-protein] S-malonyltransferase activityMolecular FunctionIEA
GO:0008610lipid biosynthetic processBiological ProcessTAS (11971939)
GO:0006633fatty acid biosynthetic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:50671