ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Fasn

Full Name:

fatty acid synthase

Organism:

Rattus norvegicus (Rat)

Chromosome:

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Fasn
Fold Change:		1.13
P Value:		0.008
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0042470	melanosome	Cellular Component	IEA
GO:0005575	cellular_component	Cellular Component	ND
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016788	hydrolase activity, acting on ester bonds	Molecular Function	IEA
GO:0016829	lyase activity	Molecular Function	IEA
GO:0031177	phosphopantetheine binding	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	IPI
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0048037	cofactor binding	Molecular Function	IEA
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	Molecular Function	IEA
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	Molecular Function	IEA
GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	Molecular Function	IEA
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase activity	Molecular Function	IEA
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	Molecular Function	IEA
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	Molecular Function	IEA
GO:0008610	lipid biosynthetic process	Biological Process	TAS (11971939)
GO:0006633	fatty acid biosynthetic process	Biological Process	IEA