ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gsk3a

Full Name:

glycogen synthase kinase 3 alpha

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

1q21

Physical Location:

80505516-80514137 on NC_005100.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2931 Symbol (Name): GSK3A (glycogen synthase kinase 3 alpha)

Ortholog Status:

The human GeneID 2931 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		50686
Fold Change:		0.642
P Value:		0.021
Note:		Fold change is average ratio of AA to ANA.

Dataset Information

Name:		15846778
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:		DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_017344.1	NP_059040.1	NC_005100.2 range: 80505516..80514137, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0004696	glycogen synthase kinase 3 activity	Molecular Function	NAS (2164470)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA (2164470)
GO:0004672	protein kinase activity	Molecular Function	ISS
GO:0050321	tau-protein kinase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS
GO:0007165	signal transduction	Biological Process	NAS (2164470)