| Gene Information |
| Gene ID: | | 51083 |
| Symbol: | | GAL |
| Full Name: | | galanin prepropeptide |
| Alias: | | GALN|GLNN|GMAP|MGC40167 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 11 |
| Genetic Location: | | 11q13.2 |
| Physical Location: | | 68208558-68215218 on NC_000011.8 |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | 18477577 | | Method: | | Addiction array gene list | | Publication: | | Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed | | Summary: | | To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior. |
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| Gene Information | | Original ID | No. of Publications | Phenotype | |
| GAL | 2 | Alcoholism | | GAL | 2 | Alcohol-Related Disorders |
| | HuGE Navigator Dataset | | Name: | | HuGE Navigator | | Method: | | Literature data mining | | Publication: | | Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008]. | | Summary: | | HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005576 | extracellular region | Cellular Component | IEA | |
| GO:0005184 | neuropeptide hormone activity | Molecular Function | NAS (1722333) | |
| GO:0006939 | smooth muscle contraction | Biological Process | NAS | |
| GO:0007218 | neuropeptide signaling pathway | Biological Process | IEA | |
| GO:0030073 | insulin secretion | Biological Process | NAS (1370155) | |
| GO:0030252 | growth hormone secretion | Biological Process | NAS | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 51083 |
| HGNC: | | 4114 |
| Ensembl: | | ENSG00000069482 |
| MIM: | | 137035 |
| HPRD: | | 00658 |
| HuGE Navigator: | | 51083 |
| dbSNP: | | GAL |
| GeneCard: | | GAL |
| AceView: | | GAL |
