ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ASB1

Full Name:

ankyrin repeat and SOCS box-containing 1

Alias:

ASB-1|KIAA1146|MGC11165

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q37

Physical Location:

239000364-239025629 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 65247 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Linkage Dataset

Marker

LOD

P value

Location (bp)

D2S2973

2.20

0.0007

235696080

D2S140

1.95

0.0014

241388318

Region:		235696080-241388318
Phenotype:		WDSFS (withdrawal symptoms factor score)
Name:		17067344
Method:		Linkage
Publication:		Kuo et al. Alcohol Clin Exp Res. (2006) Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence. PubMed
Summary:		A 4-cM dense whole-genome linkage study was conducted in the Irish Affected Sib Pair Study of Alcohol Dependence. Probands, affected siblings, and parents were evaluated by structured interview. Variance component linkage analysis was applied to data from 485 families for 5 measures: initial sensitivity and tolerance (based on scales from the self-report of the effects of ethanol; maximum drinks within 24 hours, an empirically derived factor score based on withdrawal symptoms, and age at onset of alcohol dependence.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001040445.1	NP_001035535.1	NC_000002.10 range: 239000364..239025629

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IC (11111040)
GO:0003674	molecular_function	Molecular Function	ND
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0042036	negative regulation of cytokine biosynthetic process	Biological Process	NAS (11111040)