ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ATP5G2

Full Name:

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12q13.13

Physical Location:

52345210-52356778 on NC_000012.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.524464
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Information

Original ID1:

ATP5G2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	NR
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005753	mitochondrial proton-transporting ATP synthase complex	Cellular Component	TAS (8328972)
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	Cellular Component	IEA
GO:0031966	mitochondrial membrane	Cellular Component	IEA
GO:0016469	proton-transporting two-sector ATPase complex	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	Molecular Function	IEA
GO:0005215	transporter activity	Molecular Function	NAS (8328972)
GO:0008289	lipid binding	Molecular Function	IEA
GO:0046961	hydrogen ion transporting ATPase activity, rotational mechanism	Molecular Function	IEA
GO:0015992	proton transport	Biological Process	IEA
GO:0015986	ATP synthesis coupled proton transport	Biological Process	IEA
GO:0046034	ATP metabolic process	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA