ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

GPRC5B

Full Name:

G protein-coupled receptor, family C, group 5, member B

Alias:

RAIG-2|RAIG2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

16p12

Physical Location:

19777793-19803651 on NC_000016.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.148685
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_016235.1	NP_057319.1	NC_000016.8 range: 19777793..19803651, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0008067	metabotropic glutamate, GABA-B-like receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005118	sevenless binding	Molecular Function	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007601	visual perception	Biological Process	IEA