ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PFKFB2

Full Name:

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

Alias:

DKFZp781D2217|MGC138308|MGC138310|PFK-2/FBPase-2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q31

Physical Location:

205293242-205320990 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.282702
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (9464277)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Molecular Function	IEA
GO:0003873	6-phosphofructo-2-kinase activity	Molecular Function	TAS (9652401)
GO:0003873	6-phosphofructo-2-kinase activity	Molecular Function	EXP (9464277)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006003	fructose 2,6-bisphosphate metabolic process	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA