ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PIK3C2B

Full Name:

phosphoinositide-3-kinase, class 2, beta polypeptide

Alias:

C2-PI3K|DKFZp686G16234

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q32

Physical Location:

202658383-202726096 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.497487
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002646.2	NP_002637.2	NC_000001.9 range: 202658383..202726096, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005942	phosphoinositide 3-kinase complex	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	NAS
GO:0005829	cytosol	Cellular Component	NAS
GO:0005792	microsome	Cellular Component	NAS
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0016773	phosphotransferase activity, alcohol group as acceptor	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016303	1-phosphatidylinositol-3-kinase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0035091	phosphoinositide binding	Molecular Function	IEA
GO:0004428	inositol or phosphatidylinositol kinase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10805725)
GO:0035005	phosphatidylinositol-4-phosphate 3-kinase activity	Molecular Function	NAS (9830063)
GO:0046854	phosphoinositide phosphorylation	Biological Process	IEA
GO:0008150	biological_process	Biological Process	ND
GO:0007154	cell communication	Biological Process	IEA
GO:0048015	phosphoinositide-mediated signaling	Biological Process	IEA