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Gene Information
Gene ID:5319
Symbol:PLA2G1B
Full Name:phospholipase A2, group IB (pancreas)
Alias:MGC119834|MGC119835|PLA2|PLA2A|PPLA2
Organism:Homo sapiens (Human)
Chromosome:12
Genetic Location:12q23-q24.1
Physical Location:119244296-119249974 on NC_000012.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:NM_000928
Dataset Information
Name:12065639
Method:Microarray
Tissue:Frontal and motor cortices
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000928.2NP_000919.1NC_000012.10 range: 119244296..119249974, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentIDA (7060561)
GO:0005576extracellular regionCellular ComponentIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0043498cell surface bindingMolecular FunctionIDA (1918029)
GO:0047498calcium-dependent phospholipase A2 activityMolecular FunctionIDA (7060561)
GO:0032052bile acid bindingMolecular FunctionISS (7060561)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005102receptor bindingMolecular FunctionIDA (1918029)
GO:0004623phospholipase A2 activityMolecular FunctionIEA
GO:0032431activation of phospholipase A2Biological ProcessTAS (17981679)
GO:0032637interleukin-8 productionBiological ProcessISS (15528384)
GO:0032869cellular response to insulin stimulusBiological ProcessISS (1918029)
GO:0050778positive regulation of immune responseBiological ProcessISS (16005851)
GO:0044240multicellular organismal lipid catabolic processBiological ProcessIDA (7060561)
GO:0045740positive regulation of DNA replicationBiological ProcessIDA (1918029)
GO:0046470phosphatidylcholine metabolic processBiological ProcessIDA (7060561)
GO:0050482arachidonic acid secretionBiological ProcessTAS (12423354)
GO:0050714positive regulation of protein secretionBiological ProcessTAS (17981679)
GO:0048146positive regulation of fibroblast proliferationBiological ProcessIC (1918029)
GO:0030593neutrophil chemotaxisBiological ProcessISS (16005851)
GO:0002446neutrophil mediated immunityBiological ProcessISS (16005851)
GO:0006633fatty acid biosynthetic processBiological ProcessIDA (1918029)
GO:0006644phospholipid metabolic processBiological ProcessIEA
GO:0007015actin filament organizationBiological ProcessTAS (9886417)
GO:0007165signal transductionBiological ProcessTAS (9886417)
GO:0007243protein kinase cascadeBiological ProcessISS (15528384)
GO:0010524positive regulation of calcium ion transport into cytosolBiological ProcessISS (15528384)
GO:0010552positive regulation of specific transcription from RNA polymerase II promoterBiological ProcessISS (15528384)
GO:0015758glucose transportBiological ProcessISS (1918029)
GO:0016042lipid catabolic processBiological ProcessIEA
GO:0000187activation of MAPK activityBiological ProcessISS (15528384|16005851)
GO:0019370leukotriene biosynthetic processBiological ProcessISS (16005851)
GO:0051092activation of NF-kappaB transcription factorBiological ProcessISS (15528384)
Other Database Cross Links
NCBI Entrez Gene:5319
HGNC:9030
Ensembl:ENSG00000170890
MIM:172410
HPRD:01396
HuGE Navigator:5319
dbSNP:PLA2G1B
GeneCard:PLA2G1B
AceView:PLA2G1B