ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

EXOSC10

Full Name:

exosome component 10

Alias:

PM-Scl|PM/Scl-100|PMSCL|PMSCL2|RRP6|Rrp6p|p2|p3|p4

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p36.22

Physical Location:

11049261-11082524 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		PMSCL2
Original ID2:		R40490

Dataset Information

Name:		11093800
Method:		Microarray
Tissue:		SH-SY5Y neuroblastoma cells
Phenotype:		Ethanol response
Publication:		Thibault et al. Mol Pharmacol. (2000) Expression profiling of neural cells reveals specific patterns of ethanol-responsive gene expression. PubMed
Summary:		We used oligonucleotide arrays to study nearly 6000 genes in human SH-SY5Y neuroblastoma cells exposed to chronic ethanol. A set of 42 genes had consistently increased or decreased mRNA abundance after 3 days of ethanol treatment.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000176	nuclear exosome (RNase complex)	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005730	nucleolus	Cellular Component	TAS (1383382)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS (1383382)
GO:0003723	RNA binding	Molecular Function	IEA
GO:0008408	3'-5' exonuclease activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0042802	identical protein binding	Molecular Function	IPI (15231747)
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Biological Process	IEA
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	Biological Process	IEA
GO:0006364	rRNA processing	Biological Process	IEA