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Gene Information
Gene ID:5411
Symbol:PNN
Full Name:pinin, desmosome associated protein
Alias:DRS|SDK3|memA|pinin
Organism:Homo sapiens (Human)
Chromosome:14
Genetic Location:14q21.1
Physical Location:38714137-38722172 on NC_000014.7
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.409965
Note:"Class II, up-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original ID1:PNN
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_002687.3NP_002678.2NC_000014.7 range: 38714137..38722172
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005911intercellular junctionCellular ComponentTAS (8922384)
GO:0016607nuclear speckCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0005681spliceosomeCellular ComponentIEA
GO:0005882intermediate filamentCellular ComponentTAS (10809736)
GO:0005886plasma membraneCellular ComponentTAS (8922384)
GO:0003677DNA bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (17353931)
GO:0005198structural molecule activityMolecular FunctionNAS (8922384)
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006397mRNA processingBiological ProcessIEA
GO:0007155cell adhesionBiological ProcessTAS (8922384)
GO:0008380RNA splicingBiological ProcessIEA
GO:0045786negative regulation of cell cycleBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:5411
HGNC:9162
Ensembl:ENSG00000100941
MIM:603154
HPRD:04401
HuGE Navigator:5411
dbSNP:PNN
GeneCard:PNN
AceView:PNN