ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

POLR2A

Full Name:

polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p13.1

Physical Location:

7328421-7358652 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 20020 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

POLR2A

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000937.3	NP_000928.1	NC_000017.9 range: 7328421..7358652

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005665	DNA-directed RNA polymerase II, core complex	Cellular Component	TAS (2999107)
GO:0005730	nucleolus	Cellular Component	IDA (16109376)
GO:0005665	DNA-directed RNA polymerase II, core complex	Cellular Component	NAS (3145407)
GO:0005634	nucleus	Cellular Component	NAS (7622068)
GO:0005654	nucleoplasm	Cellular Component	EXP (1939271\|2449431\|8946909\|9409616\|9512541\|9790902\|12676794)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (10075709\|10944529\|14992727)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016779	nucleotidyltransferase activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	NAS (7622068)
GO:0003899	DNA-directed RNA polymerase activity	Molecular Function	NAS (3145407\|7622068)
GO:0006350	transcription	Biological Process	IEA
GO:0006351	transcription, DNA-dependent	Biological Process	NAS (3145407)
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	EXP (8946909)
GO:0006368	RNA elongation from RNA polymerase II promoter	Biological Process	EXP (9405375)
GO:0000398	nuclear mRNA splicing, via spliceosome	Biological Process	EXP (12226669)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	NAS (7622068)