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Gene Information
Gene ID:54315
Symbol:Ucp2
Full Name:uncoupling protein 2 (mitochondrial, proton carrier)
Organism:Rattus norvegicus (Rat)
Chromosome:1
Genetic Location:1q32
Physical Location:157922178-157928517 on NC_005100.2
Gene Type:protein-coding
Human Ortholog:GeneID: 7351    Symbol (Name): UCP2 (uncoupling protein 2 (mitochondrial, proton carrier))
Ortholog Status:The human GeneID 7351 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.13333
Original ID2:Ucp2
Fold Change:1.2
P Value:0.0004
Note:higher levels in hippocampus of iP than iNP rats
Gene Information
Original ID1:Rn.13333
Original ID2:Ucp2
Fold Change:1.19
P Value:0.00371
Note:higher levels in hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019354.2NP_062227.2NC_005100.2 range: 157922178..157928517
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005743mitochondrial inner membraneCellular ComponentIPI (12372827)
GO:0005743mitochondrial inner membraneCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentISS
GO:0005739mitochondrionCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentIDA (12372827)
GO:0005488bindingMolecular FunctionIEA
GO:0005215transporter activityMolecular FunctionIEA
GO:0006810transportBiological ProcessIEA
GO:0006839mitochondrial transportBiological ProcessIDA (12372827)
GO:0006839mitochondrial transportBiological ProcessIEA
GO:0000303response to superoxideBiological ProcessIDA (12372827)
Other Database Cross Links
NCBI Entrez Gene:54315
RGD:3932
Ensembl:ENSRNOG00000017854
dbSNP:Ucp2