ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gabbr1

Full Name:

gamma-aminobutyric acid (GABA-B) receptor, 1

Alias:

GABAbR1|bM573K1.1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

17 B1|17 20.4 cM

Physical Location:

37182910-37211249 on NC_000083.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2550 Symbol (Name): GABBR1 (gamma-aminobutyric acid (GABA) B receptor, 1)

Ortholog Status:

The human GeneID 2550 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gababr1
Fold Change:		0.63
Note:		Significantly regulated by ethanol in cortical neurons

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019439.3	NP_062312.3	NC_000083.5 range: 37182910..37211249

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0045211	postsynaptic membrane	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IDA (15013631)
GO:0008067	metabotropic glutamate, GABA-B-like receptor activity	Molecular Function	ISO
GO:0004871	signal transducer activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15013631)
GO:0004965	GABA-B receptor activity	Molecular Function	IEA
GO:0004930	G-protein coupled receptor activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0007194	negative regulation of adenylate cyclase activity	Biological Process	ISO
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA