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Gene Information
Gene ID:2550
Full Name:gamma-aminobutyric acid (GABA) B receptor, 1
Organism:Homo sapiens (Human)
Genetic Location:6p21.31
Physical Location:29677983-29708838 on NC_000006.10, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 54393 Rat: 81657 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:W07715
Fold Change:1.55
P Value:2.00E-03
Tissue:Prefrontal cortex
Dataset Information
Tissue:Prefrontal cortex and nucleus accumbens
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.
Gene Information
Original ID1:Hs.167017
Note:"Class II, up-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original IDNo. of PublicationsPhenotype
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001470.2NP_001461.1NC_000006.10 range: 29677983..29708838, complement
NM_021903.2NP_068703.1NC_000006.10 range: 29677983..29708838, complement
NM_021904.2NP_068704.2NC_000006.10 range: 29677983..29708838, complement
NM_021905.2NP_068705.2NC_000006.10 range: 29677983..29708838, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0005576extracellular regionCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (9753614)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0004965GABA-B receptor activityMolecular FunctionTAS (9069281)
GO:0004965GABA-B receptor activityMolecular FunctionIEA
GO:0007194negative regulation of adenylate cyclase activityBiological ProcessTAS (9069281)
GO:0007214gamma-aminobutyric acid signaling pathwayBiological ProcessTAS (9069281)
GO:0007165signal transductionBiological ProcessIEA
GO:0006464protein modification processBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:2550
HuGE Navigator:2550