ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gabbr1

Full Name:

gamma-aminobutyric acid (GABA) B receptor 1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

20p12

Physical Location:

1553311-1582397 on NC_005119.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2550 Symbol (Name): GABBR1 (gamma-aminobutyric acid (GABA) B receptor, 1)

Ortholog Status:

The human GeneID 2550 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gabbr1
Fold Change:		-1.33
P Value:		0.005
Note:		Differential expression between ethanol and water groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031028.2	NP_112290.2	NC_005119.2 range: 1553311..1582397, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0004965	GABA-B receptor activity	Molecular Function	IMP (12054677)
GO:0004965	GABA-B receptor activity	Molecular Function	IEA
GO:0004965	GABA-B receptor activity	Molecular Function	IDA (10457184)
GO:0004872	receptor activity	Molecular Function	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0001649	osteoblast differentiation	Biological Process	IMP (12054677)