ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pqbp1

Full Name:

polyglutamine binding protein 1

Alias:

PQBP-1|Sfc2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

X A1.1|X 2.0 cM

Physical Location:

7471648-7476353 on NC_000086.6, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10084 Symbol (Name): PQBP1 (polyglutamine binding protein 1)

Ortholog Status:

The human GeneID 10084 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pqbp1
Original ID2:		AJ250406

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019478.3	NP_062351.2	NC_000086.6 range: 7471648..7476353, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005634	nucleus	Cellular Component	IEA
GO:0003674	molecular_function	Molecular Function	ND
GO:0005515	protein binding	Molecular Function	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0008150	biological_process	Biological Process	ND