ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PPA1

Full Name:

pyrophosphatase (inorganic) 1

Alias:

IOPPP|MGC111556|PP|PP1|SID6-8061

Organism:

Homo sapiens (Human)

Chromosome:

10

Genetic Location:

10q11.1-q24

Physical Location:

71632591-71663195 on NC_000010.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.437403
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021129.3	NP_066952.1	NC_000010.9 range: 71632591..71663195, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	TAS (16130169)
GO:0005829	cytosol	Cellular Component	EXP (4130389)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0004427	inorganic diphosphatase activity	Molecular Function	IEA
GO:0004427	inorganic diphosphatase activity	Molecular Function	TAS (10542310)
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0006796	phosphate metabolic process	Biological Process	IEA
GO:0006796	phosphate metabolic process	Biological Process	TAS (10542310)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000180817

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: