ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

LEPREL1

Full Name:

leprecan-like 1

Alias:

FLJ10718|MLAT4|P3H2

Organism:

Homo sapiens (Human)

Chromosome:

3

Genetic Location:

3q28

Physical Location:

191157315-191321411 on NC_000003.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.374191
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_018192.2	NP_060662.2	NC_000003.10 range: 191157315..191321411, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0031418	L-ascorbic acid binding	Molecular Function	IEA
GO:0019797	procollagen-proline 3-dioxygenase activity	Molecular Function	IEA
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	Molecular Function	IEA
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0019538	protein metabolic process	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000090530

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: