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Gene Information
Gene ID:55619
Symbol:DOCK10
Full Name:dedicator of cytokinesis 10
Alias:DKFZp781A1532|DRIP2|Nbla10300|ZIZ3
Organism:Homo sapiens (Human)
Chromosome:2
Genetic Location:2q36.2
Physical Location:225338050-225615573 on NC_000002.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.46578
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_014689.2NP_055504.2NC_000002.10 range: 225338050..225615573, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005085guanyl-nucleotide exchange factor activityMolecular FunctionIEA
GO:0005525GTP bindingMolecular FunctionIEA
GO:0051020GTPase bindingMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:55619
HGNC:23479
Ensembl:ENSG00000135905
MIM:611518
HPRD:10919
HuGE Navigator:55619
dbSNP:DOCK10
GeneCard:DOCK10
AceView:DOCK10