ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PRKACB

Full Name:

protein kinase, cAMP-dependent, catalytic, beta

Alias:

DKFZp781I2452|MGC41879|MGC9320|PKACB

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p36.1

Physical Location:

84316332-84476768 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 293508 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		M34181
Fold Change:		-2, -1.7
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005952	cAMP-dependent protein kinase complex	Cellular Component	TAS (12420224)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (12420224)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	IDA (12420224)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004691	cAMP-dependent protein kinase activity	Molecular Function	IDA (12420224)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (12420224)
GO:0007165	signal transduction	Biological Process	TAS (2342480)
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	Biological Process	TAS (12420224)
GO:0007243	protein kinase cascade	Biological Process	EXP (12721358)
GO:0009755	hormone-mediated signaling	Biological Process	EXP (12626323)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA