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Gene Information
Gene ID:293508
Symbol:Prkacb
Full Name:protein kinase, cAMP dependent, catalytic, beta
Organism:Rattus norvegicus (Rat)
Chromosome:2
Genetic Location:2q44
Physical Location:244946187-245035645 on NC_005101.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5567    Symbol (Name): PRKACB (protein kinase, cAMP-dependent, catalytic, beta)
Ortholog Status:The human GeneID 5567 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Prkacb
Fold Change:-1.29
P Value:0
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Prkacb
Fold Change:-1.29
P Value:0
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_001059642.1XP_001059642.1NC_005101.2 range: 244946187..245035645, complement
XM_215070.4XP_215070.3NC_005101.2 range: 244946187..245035645, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0005737cytoplasmCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0000287magnesium ion bindingMolecular FunctionISS
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0004691cAMP-dependent protein kinase activityMolecular FunctionISS
GO:0005524ATP bindingMolecular FunctionISS
GO:0016740transferase activityMolecular FunctionIEA
GO:0006468protein amino acid phosphorylationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:293508
RGD:1310574
Ensembl:ENSRNOG00000004978
dbSNP:Prkacb