ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Prkacb

Full Name:

protein kinase, cAMP dependent, catalytic, beta

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q44

Physical Location:

244946187-245035645 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5567 Symbol (Name): PRKACB (protein kinase, cAMP-dependent, catalytic, beta)

Ortholog Status:

The human GeneID 5567 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Prkacb
Fold Change:		-1.29
P Value:		0
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Prkacb
Fold Change:		-1.29
P Value:		0
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0000287	magnesium ion binding	Molecular Function	ISS
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004691	cAMP-dependent protein kinase activity	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	ISS
GO:0016740	transferase activity	Molecular Function	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS