ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CCDC88A

Full Name:

coiled-coil domain containing 88A

Alias:

APE|DKFZp686D0630|GIRDIN|GIV|GRDN|HkRP1|KIAA1212

Organism:

Homo sapiens (Human)

Chromosome:

2

Genetic Location:

2p16.1

Physical Location:

55368481-55500466 on NC_000002.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.292925
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_018084.3	NP_060554.3	NC_000002.10 range: 55368481..55500466, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031410	cytoplasmic vesicle	Cellular Component	IDA (15882442)
GO:0030027	lamellipodium	Cellular Component	IDA (16139227)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IDA (15882442)
GO:0005794	Golgi apparatus	Cellular Component	IDA (15882442)
GO:0005829	cytosol	Cellular Component	IDA (15749703)
GO:0005886	plasma membrane	Cellular Component	IDA (15882442)
GO:0035091	phosphoinositide binding	Molecular Function	IDA (16139227)
GO:0008017	microtubule binding	Molecular Function	ISS
GO:0042803	protein homodimerization activity	Molecular Function	IPI (16139227)
GO:0003779	actin binding	Molecular Function	IDA (16139227)
GO:0043422	protein kinase B binding	Molecular Function	IPI (16139227)
GO:0042127	regulation of cell proliferation	Biological Process	ISS
GO:0032956	regulation of actin cytoskeleton organization and biogenesis	Biological Process	IMP (16139227)
GO:0032148	activation of protein kinase B activity	Biological Process	ISS
GO:0030032	lamellipodium biogenesis	Biological Process	IMP (16139227)
GO:0016477	cell migration	Biological Process	IMP (16139227)
GO:0016044	membrane organization and biogenesis	Biological Process	IDA (15882442)
GO:0006275	regulation of DNA replication	Biological Process	ISS
GO:0001932	regulation of protein amino acid phosphorylation	Biological Process	ISS

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000115355

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: