ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PRKAR1A

Full Name:

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

Alias:

CAR|CNC|CNC1|DKFZp779L0468|MGC17251|PKR1|PPNAD1|PRKAR1|TSE1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q23-q24

Physical Location:

64019704-64040505 on NC_000017.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AY007115

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005952	cAMP-dependent protein kinase complex	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0008603	cAMP-dependent protein kinase regulator activity	Molecular Function	TAS (3426618)
GO:0008603	cAMP-dependent protein kinase regulator activity	Molecular Function	IEA
GO:0030552	cAMP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15655353\|17353931)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (1832337)
GO:0009755	hormone-mediated signaling	Biological Process	EXP (12626323)
GO:0001932	regulation of protein amino acid phosphorylation	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA