ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

PROC

Full Name:

protein C (inactivator of coagulation factors Va and VIIIa)

Alias:

PROC1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

2q13-q14

Physical Location:

127892486-127903287 on NC_000002.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.224698
Note:		"Class I, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Information

Original ID1:

PROC

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000312.2	NP_000303.1	NC_000002.10 range: 127892486..127903287

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	NAS (14718574)
GO:0005886	plasma membrane	Cellular Component	EXP (2538457)
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0003808	protein C (activated) activity	Molecular Function	EXP (2538457)
GO:0005515	protein binding	Molecular Function	IPI (15248212)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0004252	serine-type endopeptidase activity	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0003808	protein C (activated) activity	Molecular Function	TAS (15005336)
GO:0006508	proteolysis	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	NAS (12052963)
GO:0030195	negative regulation of blood coagulation	Biological Process	TAS (15005336)
GO:0043066	negative regulation of apoptosis	Biological Process	IMP (12563316)