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Gene Information
Gene ID:5624
Full Name:protein C (inactivator of coagulation factors Va and VIIIa)
Organism:Homo sapiens (Human)
Genetic Location:2q13-q14
Physical Location:127892486-127903287 on NC_000002.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.224698
Note:"Class I, down-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original ID1:PROC
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000312.2NP_000303.1NC_000002.10 range: 127892486..127903287
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentNAS (14718574)
GO:0005886plasma membraneCellular ComponentEXP (2538457)
GO:0008233peptidase activityMolecular FunctionIEA
GO:0003808protein C (activated) activityMolecular FunctionEXP (2538457)
GO:0005515protein bindingMolecular FunctionIPI (15248212)
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0004252serine-type endopeptidase activityMolecular FunctionIEA
GO:0003824catalytic activityMolecular FunctionIEA
GO:0003808protein C (activated) activityMolecular FunctionTAS (15005336)
GO:0006508proteolysisBiological ProcessIEA
GO:0006508proteolysisBiological ProcessNAS (12052963)
GO:0030195negative regulation of blood coagulationBiological ProcessTAS (15005336)
GO:0043066negative regulation of apoptosisBiological ProcessIMP (12563316)
Other Database Cross Links
NCBI Entrez Gene:5624
HuGE Navigator:5624