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Gene Information
Gene ID:56266
Symbol:Cyp4f1
Full Name:cytochrome P450, family 4, subfamily f, polypeptide 1
Alias:Cyp4f14|Cyp4f2|MGC93476
Organism:Rattus norvegicus (Rat)
Chromosome:7
Genetic Location:7q11
Physical Location:13589661-13600855 on NC_005106.2, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cyp4f2
Fold Change:1.16
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_019623.2NP_062569.2NC_005106.2 range: 13589661..13600855, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentIEA
GO:0005792microsomeCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0004497monooxygenase activityMolecular FunctionIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0020037heme bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0050381unspecific monooxygenase activityMolecular FunctionIEA
Other Database Cross Links
NCBI Entrez Gene:56266
RGD:70926
Ensembl:ENSRNOG00000004786
dbSNP:Cyp4f1