ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HTRA1

Full Name:

HtrA serine peptidase 1

Alias:

ARMD7|HtrA|L56|ORF480|PRSS11

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

10q26.3

Physical Location:

124211046-124264412 on NC_000010.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 56213 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Y07921
Fold Change:		-1.5, -1.6
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002775.4	NP_002766.1	NC_000010.9 range: 124211046..124264412

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	TAS (9852107)
GO:0004252	serine-type endopeptidase activity	Molecular Function	TAS (9852107)
GO:0005520	insulin-like growth factor binding	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0001558	regulation of cell growth	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	IEA