ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Htra1

Full Name:

HtrA serine peptidase 1

Alias:

AI429470|HTRA|L56|Prss11|RSPP11

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

7 F3

Physical Location:

138079748-138129166 on NC_000073.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5654 Symbol (Name): HTRA1 (HtrA serine peptidase 1)

Ortholog Status:

The human GeneID 5654 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Prss11
Original ID2:		AW125478

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019564.2	NP_062510.1	NC_000073.5 range: 138079748..138129166

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008233	peptidase activity	Molecular Function	IEA
GO:0019838	growth factor binding	Molecular Function	IEA
GO:0005520	insulin-like growth factor binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (14973287)
GO:0004252	serine-type endopeptidase activity	Molecular Function	IEA
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IDA (14973287)
GO:0001558	regulation of cell growth	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	IEA
GO:0030514	negative regulation of BMP signaling pathway	Biological Process	IDA (14973287)