ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

56637

Symbol:

Gsk3b

Full Name:

glycogen synthase kinase 3 beta

Alias:

7330414F15Rik|8430431H08Rik|C86142|GSK-3|GSK-3beta|GSK3

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

16 B4

Physical Location:

38089086-38246164 on NC_000082.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2932 Symbol (Name): GSK3B (glycogen synthase kinase 3 beta)

Ortholog Status:

The human GeneID 2932 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gsk3b
Fold Change:		0.47
Note:		Significantly regulated by ethanol in cortical neurons

Gene Information

Original ID1:		Gsk3b
Fold Change:		1.02
Note:		Significantly regulated in cortical neurons treated with both ethanol and nicotine

Dataset Information

Name:		17295719
Method:		Microarray
Tissue:		Cultured fetal mouse cortical neurons
Phenotype:		Ethanol response
Publication:		Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:		By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_019827.6	NP_062801.1	NC_000082.5 range: 38089086..38246164

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	ISO
GO:0043227	membrane-bounded organelle	Cellular Component	IDA (12805290)
GO:0043198	dendritic shaft	Cellular Component	IDA (12805290)
GO:0043025	cell soma	Cellular Component	IDA (12805290)
GO:0030426	growth cone	Cellular Component	IDA (12805290)
GO:0005654	nucleoplasm	Cellular Component	EXP (9832503)
GO:0005634	nucleus	Cellular Component	ISO
GO:0005634	nucleus	Cellular Component	IDA (12502791)
GO:0005829	cytosol	Cellular Component	IDA (12502791)
GO:0050321	tau-protein kinase activity	Molecular Function	IDA (15192701)
GO:0008013	beta-catenin binding	Molecular Function	IPI (12874278)
GO:0016301	kinase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004696	glycogen synthase kinase 3 activity	Molecular Function	IDA (12805290)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	ISO
GO:0004696	glycogen synthase kinase 3 activity	Molecular Function	ISS (10894547)
GO:0004672	protein kinase activity	Molecular Function	IDA (14730361)
GO:0004696	glycogen synthase kinase 3 activity	Molecular Function	ISO
GO:0002039	p53 binding	Molecular Function	ISO
GO:0005515	protein binding	Molecular Function	IPI (12432063\|12805290)
GO:0000320	re-entry into mitotic cell cycle	Biological Process	IDA (12502791)
GO:0045444	fat cell differentiation	Biological Process	IDA (12502791)
GO:0018105	peptidyl-serine phosphorylation	Biological Process	ISO
GO:0046827	positive regulation of protein export from nucleus	Biological Process	ISO
GO:0043066	negative regulation of apoptosis	Biological Process	ISO
GO:0016055	Wnt receptor signaling pathway	Biological Process	IGI (16815997)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (12432063\|12805290\|14730361\|17026964)
GO:0006611	protein export from nucleus	Biological Process	IDA (11782539)
GO:0006916	anti-apoptosis	Biological Process	IMP (10894547)
GO:0006983	ER overload response	Biological Process	IDA (14744935)
GO:0006983	ER overload response	Biological Process	ISO
GO:0007242	intracellular signaling cascade	Biological Process	ISS (14749367)
GO:0008283	cell proliferation	Biological Process	TAS (10894547)
GO:0009887	organ morphogenesis	Biological Process	IMP (10894547)
GO:0006950	response to stress	Biological Process	IDA (11782539)